Article 10119

Title of the article

PATHIOCHEMICAL RISK FACTORS OF DEVELOPMENT OF SUGAR DIABETES (LITERATURE REVIEW) 

Authors

Ereshchenko Alena Anatol'evna, Assistant, sub-department of fundamental and clinical biochemistry with laboratory diagnostics, Samara State Medical University (89 Chapaevskaya street, Samara, Russia), E-mail: bio-sam@yandex.ru
Ivanova Natal'ya Vyacheslavovna, Assistant, sub-department of fundamental and clinical biochemistry with laboratory diagnostics, Samara State Medical University (89 Chapaevskaya street, Samara, Russia), E-mail: bio-sam@yandex.ru
Potyakina Elena Evgen'evna, Assistant, sub-department of fundamental and clinical biochemistry with laboratory diagnostics, Samara State Medical University (89 Chapaevskaya street, Samara, Russia), E-mail: bio-sam@yandex.ru
Videnin Arseniy Andreevich, Student, Samara State Medical University (89 Chapaevskaya street, Samara, Russia), E-mail: bio-sam@yandex.ru
Borodina Inessa Anatol'evna, Student, Samara State Medical University (89 Chapaevskaya street, Samara, Russia), E-mail: bio-sam@yandex.ru 

Index UDK

616.379-008.64-056.52-02:577.175.722 

DOI

10.21685/2072-3032-2019-1-10 

Abstract

The article presents recent data on the prevalence of diabetes mellitus in the world and in the Russian Federation. Modifiable and unmodifiable risk factors of the development of diabetes mellitus have been identified. The peculiarities of the mechanism of realization of hypoglycemic effect of insulin in muscles, adipose tissue, liver was investigated. Molecular and biochemical pathology factors of development of type 1 and type 2 diabetes mellitus are presented. The most common mutations in the insulin gene and in the gene of the insulin receptor are described. Possible mechanisms of action of substances (triglycerides, free fatty acids and such adipokines as resistin, tumor necrosis factor-α and interleukin-6, adiponectin), which may lead to the formation of insulin resistance are described in detail. 

Key words

diabetes mellitus, insulin, insulin resistance, obesity, risk factors 

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References

1. Global'nyy doklad po diabetu. Rezyume, aprel' 2016 [Global diabetes report. Summary, April 2016]. Available at: http://www.who.int/diabetes/global-report/ru (accessed Jun. 20, 2018). [In Russian]
2. Dannye VOZ po zabolevaemosti diabetom, 2016 [WHO data on diabetes incidence]. Available at: http://www.who.int/diabetes/country-profiles/rus_ru.pdf?ua=1 (accessed Jun. 20, 2018). [In Russian]
3. Musorin E. D., Shamaeva Yu. Yu., Starshinov A. V., Pichugina N. N. Byulleten' meditsinskikh internet-konferentsiy [Bulletin of medical internet-conference]. 201, no. 5 (12), pp. 1653–1654. [In Russian]
4. Zavodnik I. B., Dremza I. K., Lapshina E. A., Cheshchevik V. T. Biologicheskie membrany [Biological membranes]. 2011, no. 28 (2), pp. 83–94. [In Russian]
5. Efimov S. V., Zgadzay Yu. O., Mikheeva O. G., Klochkov V. V. Struktura i dinamika molekulyarnykh sistem: sb. tezisov dokladov XXIV Vseros. konf. [Structure and dynamics of molecular systems: proceedings of XXIV All-Russian conference]. Yoshkar-Ola, 2017, p. 50. [In Russian]
6. Titov V. N. Klinicheskaya laboratornaya diagnostika [Clinical laboratory diagnosis]. 2014, no. 59 (6), pp. 27–40. [In Russian]
7. Dedov I. I., Mel'nichenko G. A. Sakharnyy diabet i narusheniya uglevodnogo obmena [Diabetes and carbohydrate metabolism disorders]. Moscow: Rid Elsiver, 2010, 437 p. [In Russian]
8. Zvenigorodskaya L. A., Churikova A. A. Eksperimental'naya i klinicheskaya gastroenterologiya [Experimental and clinical gastroenterology]. 2011, no. 11, pp. 73–78. [In Russian]
9. Samuel V. T., Petersen K. F., Shulman G. I. The Lancet. 2010, vol. 375 (9733), pp. 2267–2277. DOI 10.1016/S0140-6736(10)60408-4.
10. Litvitskiy P. F., Mal'tseva L. D. Voprosy sovremennoy pediatrii [Questions of modern pediatrics]. 2017, vol. 16 (5), pp. 362–369. [In Russian]
11. Tkachuk V. A., Vorotnikov A. V. Sakharnyy diabet [Diabetes]. 2014, no. 229, pp. 29–40. DOI 10.14341/DM2014229-40. [In Russian]
12. Kharlashina E. A., Kononenko I. V., Smirnova O. M., Mayorov A. Yu. Sakharnyy diabet [Diabetes]. 2011, no. 2, pp. 121–125. [In Russian]
13. Tikhonovich Yu. V., Petryaykina E. E., Rybkina I. G., Garyaeva I. V., Tyul'pakov A. N. Problemy endokrinologii [Endocrinology problems]. 2013, no. 2, pp. 45–48. [In Russian]
14. Pankov Yu. A. Molekulyarnaya biologiya [Molecular biology]. 2013, no. 47 (1), pp. 38–49. DOI 10.1134/s0026893313010135. [In Russian]
15. Pankov Yu. A. Sakharnyy diabet [Diabetes]. 2012, no. 4, pp. 11–16. DOI 10.14341/2072-0351-5532. [In Russian]
16. Khramova E. B., Lykasova I. N., Stepanova L. Yu., Khayretdinova D. M., Panasyuk M. M. Universitetskaya meditsina Urala [Ural university medicine]. 2016, no. 2, pp. 58–61. [In Russian]
17. Titov V. N. Vestnik Rossiyskoy akademii meditsinskikh nauk [Bulletin of Russian Academy of medical sciences]. 2012, no. 4, pp. 65–73. [In Russian]
18. Bondar' I. A., Shabel'nikova O. Yu. Sakharnyy diabet [Diabetes]. 2013, no. 4, pp. 11–14. [In Russian]
19. Mayorov A. Yu. Sakharnyy diabet [Diabetes]. 2011, no. 1, pp. 35–43. [In Russian]
20. Selivanova O. M., Grishin S. Yu., Glyakina A. V., Sadgyan A. S., Ushakova N. I., Galzitskaya O. V. Uspekhi biologicheskoy khimii [Advances in biological chemistry]. 2018, vol. 58, pp. 313–346. [In Russian]
21. Taranushenko T. E., Oorzhak U. S., Salmina A. B., Kiseleva N. G. Endokrinologiya [Endocrinology]. 2017, pp. 37–45. [In Russian]
22. Litvinova L. S., Kirienkova E. V., Mazunin I. O., Vasilenko M. A., Fattakhov N. S. Biomeditsinskaya khimiya [Biomedical chemistry]. 2015, no. 16 (1), pp. 70–82. DOI 10.1134/s1990750814030093. [In Russian]
23. Kim J., Wei Y., Sowers J. R. Circulation Research. 2008, vol. 102, pp. 401–414.
24. Gorbunov E. A., Brigadirova A. A., Kachaeva E. V., Putilovskiy M. A., Tarasov S. A. Problemy endokrinologii [Issues of endocrinology]. 2015, no. 6, pp. 44–54. [In Russian]
25. Cree-Green M., Gupta A., Coe G. V., Baumgartner A. D., Pyle L., Reusch J. E., Brown M. S., Newcomer B. R., Nadeau K. J. Diabetes Complications. 2017, no. 31 (1), pp. 141–148. DOI 10.1016/j.jdiacomp.2016.10.014.
26. Dedov I. I., Shestakova M. V. Sakharnyy diabet: diagnostika, lechenie, profilaktika [Diabetes: diagnosis, treatment, prevention]. Moscow: Meditsinskoe informatsionnoe agentstvo, 2011, 808 p. [In Russian]
27. Demidova T. Yu. Farmateka [Pharmacy]. 2010, no. 16, pp. 18–24. [In Russian]
28. Shagalova N. Ya. Sovremennye problemy nauki i obrazovaniya [Modern problems of science and education]. 2016, no. 2, p. 89. [In Russian]
29. Dzhavakhishvili T. Sh., Romantsova T. I., Roik O. V. Ozhirenie i metabolism [Obesity and metabolist]. 2010, no. 4, pp. 13–19. [In Russian]
30. Pashentseva A. V., Verbovoy A. F., Sharonova L. A. Ozhirenie i metabolism [Obesity and metabolist]. 2017, no. 14 (2), pp. 9–17. DOI 10.14341/omet201729-17. [In Russian]
31. Ametov A. S., Tertychnaya E. A. Lechenie i profilaktika [Treatment and prevention]. 2014, no. 3 (11), pp. 32–38. [In Russian]
32. Kovaleva Yu. V. Arterial'naya gipertenziya [Arterial hypertension]. 2015, no. 21 (4), pp. 356–370. [In Russian]
33. Verbovoy, A. F., Tsanava I. A., Verbovaya N. I., Galkin R. A. Ozhirenie i metabolism [Obesity and metabolist]. 2017, no. 14 (4), pp. 5–9. DOI 10.14341/OMET201745-9. [In Russian]
34. Drapkina O. M., Shifrina Yu. O. Arterial'naya gipertenziya [Arterial hypertension]. 2010, no. 16 (5), pp. 436–440. [In Russian]
35. Belousova O. N., Sirotina S. S., Yakunchenko T. I., Zhernakova N. I. Nauchnye vedomosti Belgorodskogo gosudarstvennogo universiteta [Bulletin of Belgorod State University]. 2015, vol. 31, no. 16 (213), pp. 12–19. [In Russian]
36. Sagirova R. I., Verbovoy A. F. RMZh [Russian medical journal]. 2017, no. 14, pp. 1039–1042. [In Russian]
37. Solntseva A. V. Meditsinskie novosti [Medical news]. 2009, no. 3, pp. 7–11. [In Russian]
38. Pal'tsev M. A., Kvetnoy I. M., Il'nitskiy A. N., Proshchaev K. I., Kvetnaya T. V., Sovenko G. N., Bessarabov V. I. Molekulyarnaya meditsina [Molecular medicine]. 2013, no. 2, pp. 3–12. [In Russian]
39. Jung C. H., Kim M. S. Archives of Pharmacal Research. 2013, vol. 36, pp. 201–207.
40. Morrison C. D., Huypens P., Stewart L. K., Gettys T. W. Biochimica et Biophysica Acta. 2009, vol. 1792, pp. 409–416.
41. Boeva L. N., Ekimova M. V., Dogadin S. A. Sibirskoe meditsinskoe obozrenie [Siberian Medical Review]. 2012, no. 1 (73), p. 11. [In Russian]
42. Kovaleva O. N., Ambrosova T. N., Ashcheulova T. V., Getman E. A. Vnutrennyaya meditsina [Internal medicine]. 2009, no. 3, pp. 18–26. [In Russian]
43. Mityukova T. A., Man'kovskaya S. V., Okulevich N. M., Platonova T. Yu., Kokhan S. B. Vestsі Natsyyanal'nay akademіі navuk Belarusі. Ser. medytsynskіkh navuk [Bulletin of National Academy of Belarus. Series: Medical sciences]. 2014, no. 1, p. 91. [In Russian]

 

Дата создания: 26.06.2019 09:20
Дата обновления: 26.06.2019 13:55